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Image Search Results
Journal: Journal of neurochemistry
Article Title: Chemogenetic approaches to identify metabolically important GPCR signaling pathways: therapeutic implications
doi: 10.1111/jnc.15314
Figure Lengend Snippet: Summary of in vivo ‘DREADD studies’ investigating signaling pathways regulating glucose and energy homeostasis. This cartoon summarizes data obtained with mutant mice expressing DREADDs in pancreatic β- and α-cells (a), adipocytes (b), hepatocytes (c), skeletal muscle cells (d), and AgRP (e) and POMC neurons (f) of the arcuate nucleus of the hypothalamus. For simplicity, only some key signaling factors/pathways and metabolic phenotypes are listed. See text for details.
Article Snippet: A recent study (
Techniques: In Vivo, Protein-Protein interactions, Mutagenesis, Expressing
Journal: Journal of neurochemistry
Article Title: Chemogenetic approaches to identify metabolically important GPCR signaling pathways: therapeutic implications
doi: 10.1111/jnc.15314
Figure Lengend Snippet: Potential therapeutic strategies to improve glucose hemostasis and/or reduce obesity, as suggested by the use of DREADD technology in mice
Article Snippet: A recent study (
Techniques: Activation Assay, Activity Assay, Inhibition, Blocking Assay, Fat
Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Article Title: Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms
doi: 10.1152/ajpregu.00086.2012
Figure Lengend Snippet: Leptin receptor-dependent lesion of arcuate nucleus (Arc) neurons by unilateral leptin conjugated to saporin (Lep-SAP) injection. A: representative immunohistochemical (IHC) images of alpha-melanocyte stimulating hormone (α-MSH) and agouti gene-related peptide (AGRP) neurons after unilateral injection of Lep-SAP into the Arc in Sprague-Dawley (S/D) or Zucker fa/fa (Zucker) rats. Calibration bar = 100 μm. Numbers of α-MSH-positive (B) and AGRP-positive (C) cell bodies in the Arc of S/D or Zucker fa/fa rats (n = 3 or 4 rats per group) after unilateral injection of Lep-SAP or control blank saporin (B-SAP). Quantified data are shown for four hypothalamic levels, each indicated in millimeters caudal to bregma. *P < 0.001 vs. the noninjected (contralateral) side.
Article Snippet: A : representative immunohistochemical (IHC) images of alpha-melanocyte stimulating hormone (α-MSH) and agouti gene-related
Techniques: Injection, Immunohistochemical staining